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How HollandPTC works to enhance the benefits of proton therapy

 

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HollandPTC

Voor de beste protonentherapie van nu en later

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Patiënten

Patientenzorg

Gezond weefsel beter sparen Dat is het voordeel van protonentherapie.

Bekijk
Over de behandeling Waarom protonentherapie Algemene informatie Soorten kanker Ervaringen van patiënten Tips en adviezen Second opinion Jongvolwassen en kanker Lopende studies
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Praktische informatie Vergoeding van uw behandeling Uw dossier
Research

Research

How HollandPTC works to enhance the benefits of proton therapy

 

View
Research at HollandPTC Our principal investigators Organisations & collaborations Research projects
Facilities Pre-clinical and clinical facilities Our research database: how to request data Doing proton research or use our facilities
Practical information Practical information on Varian projects R&D communication box Contact
HollandPTC

HollandPTC

Voor de beste protonentherapie van nu en later

Over HollandPTC
Over HollandPTC Onze visie: Samen beter, beter samen Ons team HollandPTC software
Vrienden van Cliëntenraad Diversiteit en gelijkheid

On-line adaptive proton therapy for cervical cancer to reduce the impact on morbidity and the immune system

Principal Investigators: Prof. dr. Remi Nout (Erasmus MC) and dr. Jeremy Schiphof-Godart (Erasmus MC)

PhD students: Sander Kuipers (Erasmus MC), Anouk Corbeau (LUMC)

Funding: HollandPTC-Varian 2019

Description

PT can substantially reduce the unwanted exposure of OAR to radiation dose for women with locally advanced cervical cancer. The resulting reductions in morbidity have the potential to importantly improve quality of life and functioning of these women. In addition, the bone marrow-sparing effect of PT may reduce the considerable immune suppressive impact of the current state of the art photon techniques, which may in turn increase the likelihood of safe and effective delivery of additional systemic (immune) therapies. This is especially relevant in patients at high risk of distant metastasis.

To advance the treatment of women with cervical cancer and enable the implementation of PT in the coming years, two main conditions need to be met. Firstly, (model based) indication algorithms for PT need to be developed and validated. Such model based indication algorithms may take into account the expected reduced morbidity, risk status, and expected overall survival. Development and validation in prospective clinical (trial) datasets of model-based indication algorithms is part of this proposal and will serve as an important source of evidence to reach consensus on PT indications on a national level. In addition, the results of the clinical pilot study will provide important realistic estimates of gains that can be achieved using daily adaptive IMPT in this setting. Secondly, the technical aspects of optimal PT delivery need to be optimized and implemented for cervical cancer. The targets and OAR for cervical cancer demonstrate a much bigger range of day-to-day variations in shape, position and density than tumours that are currently being treated with PT, such as head and neck cancer. Techniques for daily adaptive intensity-modulated PT using plan-libraries will be developed and translated into clinical practice as part of the current proposal.