Publication list

Tepeli, YI; Seale, C; Gonçalves, JP, ELISL: early-late integrated synthetic lethality prediction in cancer, Bioinformatics, 2024, https://doi.org/10.1093/bioinformatics/btad764

Peters, N; Taasti, VT; Ackermann, B; Bolsi, A; Dahlgren, CV; Ellerbrock, M; Fracchiolla, F; Gomà, C; Góra, J; Lopes, PC; Rinaldi, I; Salvo, K; Tarp, IS; Vai, A; Bortfeld, T; Lomax, A; Richter, C; Wohlfahrt, P, Response to Letter regarding Consensus guide on CT-based prediction of stopping-power ratio using a Hounsfield look-up table for proton therapy, Radiotherapy and Oncology, 2024, https://doi.org/10.1016/j.radonc.2023.109961

Spruijt, K; Mossahebi, S; Lin, HB; Lee, E; Kraus, J; Dhabaan, A; Poulsen, P; Lowe, M; Ayan, A; Spiessens, S; Godart, J; Hoogeman, M, Multi-institutional consensus on machine QA for isochronous cyclotron-based systems delivering ultra-high dose rate (FLASH) pencil beam scanning proton therapy in transmission mode, Medical Physics, 2024, https://doi.org/10.1002/mp.16854

Akolawala, Q; Keuning, F; Rovituso, M; van Burik, W; van der Wal, E; Versteeg, HH; Rondon, AMR; Accardo, A, Micro-Vessels-Like 3D Scaffolds for Studying the Proton Radiobiology of Glioblastoma-Endothelial Cells Co-Culture Models, Advanced Healthcare Materials, 2024, https://doi.org/10.1002/adhm.202302988

Tseng, CH; Jaspers, J; Romero, AM; Wielopolski, P; Smits, M; van Osch, MJP; Vos, F, Improved reliability of perfusion estimation in dynamic susceptibility contrast MRI by using the arterial input function from dynamic contrast enhanced,  MRINMR in Biomedicine, 2024, https://doi.org/10.1002/nbm.5038

Oud, M; Breedveld, S; Rojo-Santiago, J; Gizynska, MK; Kroesen, M; Habraken, S; Perkó, Z; Heijmen, B; Hoogeman, M, A fast and robust constraint-based online re-optimization approach for automated online adaptive intensity modulated proton therapy in head and neck cancer, Physics in Medicine and Biology, 2024, https://doi.org/10.1088/1361-6560/ad2a98

Kong, W; Oud, M; Habraken, SJM; Huiskes, M; Astreinidou, E; Rasch, CRN; Heijmen, BJM; Breedveld, SSISS-MCO: large scale sparsity-induced spot selection for fast and fully-automated robust multi-criteria optimisation of proton plans, Physics in Medicine and Biology, 2024, https://doi.org/10.1088/1361-6560/ad1e7a

Fleury, E; Herault, J; Spruijt, K; Kouwenberg, J; Angellier, G; Hofverberg, P; Horwacik, T; Kajdrowicz, T; Pignol, JP; Hoogeman, M; Trnková, P, A generalized model for monitor units determination in ocular proton therapy using machine learning: A proof-of-concept study, Physics in Medicine and Biology, 2024, https://doi.org/10.1088/1361-6560/ad1d68

Lauwers, I; Pachler, KS; Capala, ME; Sijtsema, ND; Van Gent, DC; Rovituso, M; Hoogeman, MS; Verduijn, GM; Petit, SF, Ex vivo radiation sensitivity assessment for individual head and neck cancer patients using deep learning-based automated nuclei and DNA damage foci detection, Clinical and Translational Radiation Oncology, 2024, https://doi.org/10.1016/j.ctro.2024.100735

Knäusl, B; Belotti, G; Bertholet, J; Daartz, J; Flampouri, S; Hoogeman, M; Knopf, AC; Lin, HB; Moerman, A; Paganelli, C; Rucinski, A; Schulte, R; Shimizu, S; Stützer, K; Zhang, XD; Zhang, Y; Czerska, KA review of the clinical introduction of 4D particle therapy research concepts, Physics & Imaging in Radiation Oncology, 2024, https://doi.org/10.1016/j.phro.2024.100535

Akolawala, Q; Keuning, F; Rovituso, M; van Burik, W; van der Wal, E; Versteeg, HH; Rondon, AMR; Accardo, A, Micro-Vessels-Like 3D Scaffolds for Studying the Proton Radiobiology of Glioblastoma-Endothelial Cells Co-Culture Models, Advanced Healthcare Materials, 2023, https://doi.org/10.1002/adhm.202302988

Heemskerk, T; van de Kamp, G; Essers, J; Kanaar, R; Paul, MWMulti-scale cellular imaging of DNA double strand break repair,  DNA REPAIR, 2023, https://doi.org/10.1016/j.dnarep.2023.103570

Koetsier, KS; Oud, M; de Klerck, E; Hensen, EF; Van Vulpen, M; Van Linge, A; Benthem, PPV; Slagter, C; Habraken, SJM; Hoogeman, MS; Romero, AM, Cochlear-optimized treatment planning in photon and proton radiosurgery for vestibular schwannoma patients, Clinical and Translational Radiation Oncology, 2023, https://doi.org/10.1016/j.ctro.2023.100689

den Boer, R; Siang, KNW; Yuen, M; Borggreve, A; Defize, I; van Lier, A; Ruurda, J; van Hillegersberg, R; Mook, S; Meijer, GA robust semi-automatic delineation workflow using denoised diffusion weighted magnetic resonance imaging for response assessment of patients with esophageal cancer treated with neoadjuvant chemoradiotherapy, Physics & Imaging In Radiation Oncology, 2023, https://doi.org/10.1016/j.phro.2023.100489

Tseng, CH; Jaspers, J; Romero, AM; Wielopolski, P; Smits, M; van Osch, MJP; Vos, Improved reliability of perfusion estimation in dynamic susceptibility contrast MRI by using the arterial input function from dynamic contrast enhanced,  MRINMR in Biomedicine, 2023, https://doi.org/10.1002/nbm.5038

Rojo-Santiago, J; Habraken, SJM; Romero, AM; Lathouwers, D; Wang, YB; Perko, Z; Hoogeman, MS, Robustness analysis of CTV and OAR dose in clinical PBS-PT of neuro-oncological tumors: prescription-dose calibration and inter-patient variation with the Dutch proton robustness evaluation protocol, Physics in Medicine and Biology, 2023, https://doi.org/10.1088/1361-6560/acead1

Groenendijk, CF; Rovituso, M; Lathouwers, D; Brown, JMCA,  Geant4 based simulation platform of the HollandPTC R&D proton beamline for radiobiological studies, Physica Medica-European Journal of Medical Physics, 2023, https://doi.org/10.1016/j.ejmp.2023.102643

Kuipers, S; Godart, J; Corbeau, A; Sharfo, AW; Breedveld, S; Mens, JW; de Boer, S; Nout, R; Hoogeman, M, The impact of bone marrow sparing on organs at risk dose for cervical cancer: a Pareto front analysis, Frontiers in Oncology, 2023, https://doi.org/10.3389/fonc.2023.1138433

Rojo-Santiago, J; Korevaar, E; Perkó, Z; Both, S; Habraken, SJM; Hoogeman, MSPTV-based VMAT vs. robust IMPT for head-and-neck cancer: A probabilistic uncertainty analysis of clinical plan evaluation with the Dutch model-based selection, Radiotherapy and Oncology, 2023, https://doi.org/10.1016/j.radonc.2023.109729

van Blaaderen, JJ; van der Sar, S; Onggo, D; Sheikh, MAK; Schaart, DR; Birowosuto, MD; Dorenbos, P(BZA)2PbBr4: A potential scintillator for photon-counting computed tomography detectors, Journal of Luminescence, 2023, https://doi.org/10.1016/j.jlumin.2023.120012

Elbers, JBW; Gunsch, PA; Debets, R; Keereweer, S; van Meerten, E; Zindler, J; van Norden, Y; Hoogeman, MS; Verduijn, GM; Kroesen, M; Nout, RA, HYpofractionated, dose-redistributed RAdiotherapy with protons and photons to combat radiation-induced immunosuppression in head and neck squamous cell carcinoma: study protocol of the phase I HYDRA trial, BMC Cancer, 2023, https://doi.org/10.1186/s12885-023-11031-w

Jaarsma-Coes, MG; Klaassen, L; Marinkovic, M; Luyten, GPM; Vu, THK; Ferreira, TA; Beenakker, JWM, Magnetic Resonance Imaging in the Clinical Care for Uveal Melanoma Patients-A Systematic Review from an Ophthalmic Perspective, Cancers, 2023, https://doi.org/10.3390/cancers15112995

Tang, MCY; Ferreira, TA; Marinkovic, M; Jaarsma-Coes, MG; Klaassen, L; Vu, THK; Creutzberg, CL; Rodrigues, MF; Horeweg, N; Klaver, YLB; Rasch, CRN; Luyten, GPM; Beenakker, JWM, MR-based follow-up after brachytherapy and proton beam therapy in uveal melanoma, Neuroradiology, 2023, https://doi.org/10.1007/s00234-023-03166-1

Peters, N; Taasti, VT; Ackermann, B; Bolsi, A; Dahlgren, CV; Ellerbrock, M; Fracchiolla, F; Gomà, C; Góra, J; Lopes, PC; Rinaldi, I; Salvo, K; Tarp, IS; Vai, A; Bortfeld, T; Lomax, A; Richter, C; Wohlfahrt, P, Consensus guide on CT-based prediction of stopping-power ratio using a Hounsfield look-up table for proton therapy, Radiotherapy and oncology, 2023, https://doi.org/10.1016/j.radonc.2023.109675

Trnkova, P; Zhang, Y; Toshito, T; Heijmen, B; Richter, C; Aznar, MC; Albertini, F; Bolsi, A; Daartz, J; Knopf, AC; Bertholet, JA survey of practice patterns for adaptive particle therapy for interfractional changes, Physics & Imaging In Radiation Oncology, 2023, https://doi.org/10.1016/j.phro.2023.100442

Jaspers, JPM; Taal, W; van Norden, Y; Zindler, JD; Swaak, AT; Habraken, SJM; Hoogeman, MS; Nout, R; van den Bent, MJ; Romero, AM, Early and late contrast enhancing lesions after photon radiotherapy for IDH mutated grade 2 diffuse glioma, Radiotherapy and Oncology, 2023, https://doi.org/10.1016/j.radonc.2023.109674

Meric, I; Alagoz, E; Hysing, LB; Kögler, T; Lathouwers, D; Lionheart, WRB; Mattingly, J; Obhodas, J; Pausch, G; Pettersen, HES; Ratliff, HN; Rovituso, M; Schellhammer, SM; Setterdahl, LM; Skjerdal, K; Sterpin, E; Sudac, D; Turko, JA; Ytre-Hauge, KS, A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy, Scientific Reports, 2023, https://doi.org/10.1038/s41598-023-33777-w

Pastor-Serrano, O; Habraken, S; Hoogeman, M; Lathouwers, D; Schaart, D; Nomura, Y; Xing, L; Perkó, ZA, probabilistic deep learning model of inter-fraction anatomical variations in radiotherapy, Physics in Medicine and Biology, 2023, https://doi.org/10.1088/1361-6560/acc71d

Zhang, Y; Trnkova, P; Toshito, T; Heijmen, B; Richter, C; Aznar, M; Albertini, F; Bolsi, A; Daartz, J; Bertholet, J; Knopf, AA survey of practice patterns for real-time intrafractional motion-management in particle therapy, Physics & Imaging In Radiation Oncology, 2023, https://doi.org/10.1016/j.phro.2023.100439

Matalliotakis, A; Verweij, MD, Computation of ultrasound propagation in a population of nonlinearly oscillating microbubbles including multiple scattering, Journal of The Acoustical Society of America, 2023, https://doi.org/10.1121/10.0017770

Collado-Lara, G; Heymans, SV; Rovituso, M; Sterpin, E; D’hooge, J; Vos, HJ; Abeele, KV; de Jong, NAnalytic prediction of droplet vaporization events to estimate the precision of ultrasound-based proton range verification, 2023, https://doi.org/10.1002/mp.16327

Douwes, JPJ; Koetsier, KS; van Dam, VS; Plotkin, SR; Barker, FG; Welling, DB; Jansen, JC; Hensen, EF; Shih, HA, Proton Radiotherapy for Vestibular Schwannomas in Patients with NF2-Related Schwannomatosis: A Case Series, Current Oncology, 2023, https://doi.org/10.3390/curroncol30030263

Huiskes, M; Astreinidou, E; Kong, W; Breedveld, S; Heijmen, B; Rasch, CDosimetric impact of adaptive proton therapy in head and neck cancer-A review, Clinical And Translational Radiation Oncology, 2023, https://doi.org/10.1016/j.ctro.2023.100598

Pastor-Serrano, O; Dong, P; Huang, C; Xing, L; Perkó, Z, Sub-second photon dose prediction via transformer neural networks, Medical Physics, 2023, https://doi.org/10.1002/mp.16231

Jaarsma-Coes, MG; Ferreira, TA; Marinkovic, M; Vu, THK; van Vught, L; Haren, GRV; Rodrigues, MF; Klaver, YLB; Verbist, BM; Luyten, GPM; Rasch, CRN; Beenakker, JWM, Comparison of Magnetic Resonance Imaging-Based and Conventional Measurements for Proton Beam Therapy of Uveal Melanoma, Ophthalmology Retina, 2023, https://doi.org/10.1016/j.oret.2022.06.019

Koetsier, KS; Mehan, WA; Buch, K; Welling, DB; van Benthem, PPG; Hensen, EF; Shih, HA, Labyrinthine Fluid Signal Intensity on T2-Weighted MR Imaging in Patients With Vestibular Schwannomas Undergoing Proton Radiotherapy: A Longitudinal Assessment, Otology & Neurotology, 2023, https://doi.org/10.1097/MAO.0000000000003774

Santo, RJ; Habraken, SJM; Breedveld, S; Hoogeman, MS, Pencil-beam Delivery Pattern Optimization Increases Dose Rate for Stereotactic FLASH Proton Therapy, International Journal Of Radiation Oncology Biology Physics, 2023, https://doi.org/10.1016/j.ijrobp.2022.08.053

Schimmel, J; Muñoz-Subirana, N; Kool, H; van Schendel, R; van der Vlies, S; Kamp, JA; de Vrij, F; Kushner, SA; Smith, GCM; Boulton, SJ; Tijsterman, M, Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways, Cell Reports, 2023, https://doi.org/10.1016/j.celrep.2023.112019

Burlacu, T; Lathouwers, D; Perkó, ZA, Deterministic Adjoint-Based Semi-Analytical Algorithm for Fast Response Change Computations in Proton Therapy, Journal of Computational and Theoretical Transport, 2023, https://doi.org/10.1080/23324309.2023.2166077

Jaarsma-Coes, MG; Klaassen, L; Verbist, BM; Vu, THK; Klaver, YLB; Rodrigues, MF; Nabarro, C; Luyten, GPM; Rasch, CRN; van Herk, M; Beenakker, JWM, Inter-Observer Variability in MR-Based Target Volume Delineation of Uveal Melanoma, Advances in Radiation Oncology, 2023, https://doi.org/10.1016/j.adro.2022.101149

Capala, ME; Pachler, KS; Lauwers, I; de Korte, MA; Verkaik, NS; Mast, H; Jonker, BP; Sewnaik, A; Hardillo, JA; Keereweer, S; Monserez, D; Koljenovic, S; Mostert, B; Verduijn, GM; Petit, S; van Gent, DC, Ex Vivo Functional Assay for Evaluating Treatment Response in Tumor Tissue of Head and Neck Squamous Cell Carcinoma, Cancers, 2023, https://doi.org/10.3390/cancers15020478

Chen, YH; Blommestein, HM; Klazenga, R; Groot, CUD; van Vulpen, M, Costs of Newly Funded Proton Therapy Using Time-Driven Activity-Based Costing in The Netherlands, Cancers, 2023, https://doi.org/10.3390/cancers15020516

Schimmel, J; van Wezel, MD; van Schendel, R; Tijsterman, M, Chromosomal breaks at the origin of small tandem DNA duplications, Bioessays, 2023, https://doi.org/10.1002/bies.202200168

Koetsier, KS; Locher, H; Koot, RW; van der Mey, AGL; van Benthem, PPG; Jansen, JC; Hensen, EF, The Course of Hearing Loss in Patients With a Progressive Vestibular Schwannoma, Otolaryngology-Head And Neck Surgery, 2023, https://doi.org/10.1002/ohn.277

Oud, M; Breedveld, S; Gizynska, M; Kroesen, M; Hutschemaekers, S; Habraken, S; Petit, S; Perkó, Z; Heijmen, B; Hoogeman, M, An online adaptive plan library approach for intensity modulated proton therapy for head and neck cancer, Radiotherapy and Oncology, 2022, https://doi.org/10.1016/j.radonc.2022.09.011

Habraken, S; Breedveld, S; Groen, J; Nuyttens, J; Hoogeman, M, Trade-off in healthy tissue sparing of FLASH and fractionation in stereotactic proton therapy of lung lesions with transmission beams, Radiotherapy and Oncology, 2022, https://doi.org/10.1016/j.radonc.2022.08.015.

Klaassen, L; Jaarsma-Coes, MG; Verbist, BM; Vu, THK; Marinkovic, M; Rasch, CRN; Luyten, GPM; Beenakker, JWMAutomatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma, Physics & Imaging in Radiation Oncology, 2022, https://doi.org/10.1016/j.phro.2022.11.001

Seale, C; Tepeli, Y; Gonçalves, JP, Overcoming selection bias in synthetic lethality prediction, Bioinformatics, 2022, https://doi.org/10.1093/bioinformatics/btac523

van Schendel, R; Schimmel, J; Tijsterman, MSIQ: easy quantitative measurement of mutation profiles in sequencing data NAR Genomics And Bioinformatics, 2022, https://doi.org/10.1093/nargab/lqac063.

Bogers, SLC; Petoukhova, AL; Penninkhof, JJ; Mast, ME; Poortmans, PM; Hoogeman, MS; Struikmans, HTarget Volume Coverage and Organ at Risk Doses for Left-sided Whole-breast Irradiation With or Without Internal Mammary Chain Irradiation: A Comparison Between Three Techniques Representing the Past and the Present, Clinical Oncology, 2022, https://doi.org/10.1016/j.clon.2022.04.004

van der Heyden, B; Heymans, SV; Carlier, B; Collado-Lara, G; Sterpin, E; D’hooge, JDeep learning for dose assessment in radiotherapy by the super-localization of vaporized nanodroplets in high frame rate ultrasound imaging, Physics in Medicine and Biology, 2022, https://doi.org/10.1088/1361-6560/ac6cc3

Heymans, SV; Collado-Lara, G; Rovituso, M; Vos, HJ; D’hooge, J; de Jong, N; Van Den Abeele, KAcoustic Modulation Enables Proton Detection With Nanodroplets at Body Temperature, IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, 2022, https://doi.org/10.1109/TUFFC.2022.3164805

Pastor-Serrano, O; Perkó, Z, Millisecond speed deep learning based proton dose calculation with Monte Carlo accuracy, Physics in Medicine and Biology, 2022, https://doi.org/10.1088/1361-6560/ac692e

Toumia, Y; Pullia, M; Domenici, F; Facoetti, A; Ferrarini, M; Heymans, SV; Carlier, B; van den Abeele, K; Sterpin, E; D’hooge, J; D’Agostino, E; Paradossi, G, Ultrasound-assisted carbon ion dosimetry and range measurement using injectable polymer-shelled phase-change nanodroplets: in vitro study, Scientific Reports, 2022, https://doi.org/10.1038/s41598-022-11524-x

Akolawala, Q; Rovituso, M; Versteeg, HH; Rondon, AMR; Accardo, AEvaluation of Proton-Induced DNA Damage in 3D-Engineered Glioblastoma Microenvironments, ACS Applied Materials & Interfaces, 2022, https://doi.org/10.1021/acsami.2c03706

Fleury, E; Trnkova, P; van Rij, C; Rodrigues, M; Klaver, Y; Spruijt, K; Naus, N; Zolnay, A; Pignol, JP; Kilic, E; Hoogeman, MSImproving organs-at-risk sparing for choroidal melanoma patients: A CT-based two-beam strategy in ocular proton therapy with a dedicated eyeline, Radiotherapy and Oncology, 2022, https://doi.org/10.1016/j.radonc.2022.04.021

Chen, YH; Molenaar, D; Uyl-de Groot, CA; van Vulpen, M; Blommestein, HM, Medical Resource Use and Medical Costs for Radiotherapy-Related Adverse Effects: A Systematic Review, Cancers, 2022, https://doi.org/10.3390/cancers14102444

Boersma, LJ; Sattler, MGA; Maduro, JH; Bijker, N; Essers, M; van Gestel, CMJ; Klaver, YLB; Petoukhova, AL; Rodrigues, MF; Russell, NS; van der Schaaf, A; Verhoeven, K; van Vulpen, M; Schuit, E; Langendijk, JA, Model-Based Selection for Proton Therapy in Breast Cancer: Development of the National Indication Protocol for Proton Therapy and First Clinical Experiences, Clinical Oncology, 2022, https://doi.org/10.1016/j.clon.2021.12.007

Kalisvaart, GM; van Velden, FHP; Hernández-Girón, I; Meijer, KM; Ghesquiere-Dierickx, LMH; Brink, WM; Webb, A; de Geus-Oei, LF; Slump, CH; Kuznetsov, DV; Schaart, DR; Grootjans, W, Design and evaluation of a modular multimodality imaging phantom to simulate heterogeneous uptake and enhancement patterns for radiomic quantification in hybrid imaging: A feasibility study, Medical Physics, 2022, https://doi.org/10.1002/mp.15537

Deurvorst, FR; Lara, GC; Matalliotakis, A; Vos, HJ; de Jong, N; Daeichin, V; Verweij, MDA spatial and temporal characterisation of single proton acoustic waves in proton beam cancer therapy, Journal of the Acoustical Society of America, 2022, https://doi.org/10.1121/10.0009567.

Tambas, M; van der Laan, HP; Steenbakkers, RJHM; Doyen, J; Timmermann, B; Orlandi, E; Hoyer, M; Haustermans, K; Georg, P; Burnet, NG; Gregoire, V; Calugaru, V; Troost, EGC; Hoebers, F; Calvo, FA; Widder, J; Eberle, F; van Vulpen, M; Maingon, P; Skóra, T; Weber, DC; Bergfeldt, K; Kubes, J; Langendijk, JA, Current practice in proton therapy delivery in adult cancer patients across Europe, Radiotherapy and Oncology, 2022, https://doi.org/10.1016/j.radonc.2021.12.004.

Collado-Lara, G; Heymans, SV; Rovituso, M; Carlier, B; Toumia, Y; Verweij, M; Paradossi, G; Sterpin, E; Vos, HJ; D’hooge, J; de Jong, N; Van den Abeele, K; Daeichin, V, Spatiotemporal distribution of nanodroplet vaporization in a proton beam using real-time ultrasound imaging for range verification, Ultrasound In Medicine And Biology, 2022, https://doi.org/10.1016/j.ultrasmedbio.2021.09.009

Kroesen, M; Miladinovic, V; Hutschemaekers, SAJ; Jacobs, J; van der Vos, C; Wolf, AL; Hoogeman, MS; van Vulpen, M; Bloem, JL; Dijkstra, SPDS; Peul, WC; Penninkhof, JJ; Krol, ADG, Single-institution clinical experience using robust intensity modulated proton therapy in chordoma and chondrosarcoma of the mobile spine and sacrum: Feasibility and need for plan adaptation, Radiotherapy and Oncology, 2022, https://doi.org/10.1016/j.radonc.2021.11.020

Tang, MCY; Jaarsma-Coes, MG; Ferreira, TA; Fonk, LZG; Marinkovic, M; Luyten, GPM; Beenakker, JWMA Comparison of 3 T and 7 T MRI for the Clinical Evaluation of Uveal Melanoma, Journal Of Magnetic Resonance Imaging, 2022, https://doi.org/10.1002/jmri.27939

Jaarsma-Coes, MG; Ferreira, TA; van Houdt, PJ; van der Heide, UA; Luyten, GPM; Beenakker, JWM, Eye-specific quantitative dynamic contrast-enhanced MRI analysis for patients with intraocular masses, Magnetic Resonance Materials In Physics Biology And Medicine, 2022, https://doi.org/10.1007/s10334-021-00961-w

De Roeck, L; van der Weide, HL; Eekers, DBP; Kramer, MC; Alapetite, C; Blomstrand, M; Burnet, NG; Calugaru, V; Coremans, IEM; Di Perri, D; Harrabi, S; Iannalfi, A; Klaver, YLB; Langendijk, JA; Romero, AM; Paulsen, F; Roelofs, E; de Ruysscher, D; Timmermann, B; Vitek, P; Weber, DC; Whitfield, GA; Nyström, PW; Zindler, J; Troost, EGC; Lambrecht, M, The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation, Radiotherapy and Oncology, 2022, https://doi.org/10.1016/j.radonc.2022.01.018

Pastor-Serrano, O; Habraken, S; Lathouwers, D; Hoogeman, M; Schaart, D; Perkó, Z, How should we model and evaluate breathing interplay effects in IMPT?, Physics in Medicine And Biology, 2021, https://doi.org/10.1088/1361-6560/ac383f.

Koetsier, KS; Hensen, EF; Niemierko, A; Dewyer, NA; Chapman, PH; Lamba, N; Bussière, MR; van Vulpen, M; McKenna, MJ; Loeffler, JS; Shih, HA, Outcome and Toxicity of Proton Therapy for Vestibular Schwannoma: A Cohort Study, Otology & Neurotology, 2021, https://doi.org/10.1097/MAO.0000000000003313.

Marinkovic, M; Pors, LJ; van den Berg, V; Peters, FP; Schalenbourg, A; Zografos, L; Pica, A; Hrbacek, J; Van Duinen, SG; Vu, THK; Bleeker, JC; Rasch, CRN; Jager, MJ; Luyten, GPM; Horeweg, N, Clinical Outcomes after International Referral of Uveal Melanoma Patients for Proton Therapy, Cancers, 2021, https://doi.org/10.3390/cancers13246241.

Jagt, TZ; Breedveld, S; Hoogeman, MS, Evaluation of alternative parameter settings for dose restoration and full plan adaptation in IMPT for prostate cancer, Physica Medica-European Journal of Medical Physics, 2021, https://doi.org/10.1016/j.ejmp.2021.11.003.

Corbeau, A; Kuipers, SC; de Boer, SM; Horeweg, N; Hoogeman, MS; Godart, J; Nout, RA, Correlations between bone marrow radiation dose and hematologic toxicity in locally advanced cervical cancer patients receiving chemoradiation with cisplatin: a systematic review, Radiotherapy And Oncology, 2021, https://doi.org/10.1016/j.radonc.2021.09.009.

Hassan, MK; Fleury, E; Shamonin, D; Fonk, LG; Marinkovic, M; Jaarsma-Coes, MG; Luyten, GPM; Webb, A; Beenakker, JW; Stoel, BAn Automatic Framework to Create Patient-specific Eye Models From 3D Magnetic Resonance Images for Treatment Selection in Patients With Uveal Melanoma, Advances in Radiation Oncology, 2021, https://doi.org/10.1016/j.adro.2021.100697.

Corbeau, A; Nout, RA; Mens, JWM; Horeweg, N; Godart, J; Kerkhof, EM; Kuipers, SC; van Poelgeest, MIE; Kroep, JR; Boere, IA; van Doorn, HC; Hoogeman, MS; van der Heide, UA; Putter, H; Welters, MJP; van der Burg, SH; Creutzberg, CL; de Boer, SMPROTECT: Prospective Phase-II-Trial Evaluating Adaptive Proton Therapy for Cervical Cancer to Reduce the Impact on Morbidity and the Immune System, Cancers, 2021, https://doi.org/10.3390/cancers13205179.

van de Kamp, G; Heemskerk, T; Kanaar, R; Essers, JDNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation, Frontiers In Genetics, 2021, https://doi.org/10.3389/fgene.2021.738230.

Rojo-Santiago, J; Habraken, SJM; Lathouwers, D; Romero, AM; Perkó, Z; Hoogeman, MS, Accurate assessment of a Dutch practical robustness evaluation protocol in clinical PT with pencil beam scanning for neurological tumors, Radiotherapy And Oncology, 2021, https://doi.org/10.1016/j.radonc.2021.07.028.

Pastor-Serrano, O; Lathouwers, D; Perkó, Z, A semi-supervised autoencoder framework for joint generation and classification of breathing, Computer Methods And Programs In Biomedicine, 2021, https://doi.org/10.1016/j.cmpb.2021.106312.

Schimmel, J; Muñoz-Subirana, N; Kool, H; van Schendel, R; Tijsterman, M, Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini, Nature Communications, 2021, https://doi.org/10.1038/s41467-021-25154-w.

Peters, N; Wohlfahrt, P; Dahlgren, CV; de Marzi, L; Ellerbrock, M; Fracchiolla, F; Free, J; Gomà, C; Góra, J; Jensen, MF; Kajdrowicz, T; Mackay, R; Molinelli, S; Rinaldi, I; Rompokos, V; Siewert, D; van der Tol, P; Vermeren, X; Nyström, H; Lomax, A; Richter, C, Experimental assessment of inter-centre variation in stopping-power and range prediction in particle therapy, Radiotherapy and Oncology, 2021, https://doi.org/10.1016/j.radonc.2021.07.019.

Fleury, E; Trnková, P; Spruijt, K; Herault, J; Lebbink, F; Heufelder, J; Hrbacek, J; Horwacik, T; Kajdrowicz, T; Denker, A; Gerard, A; Hofverberg, P; Mamalui, M; Slopsema, R; Pignol, JP; Hoogeman, MCharacterization of the HollandPTC proton therapy beamline dedicated to uveal melanoma treatment and an interinstitutional comparison, Medical Physics, 2021, https://doi.org/10.1002/mp.15024.

Langendijk, JA; Hoebers, FJP; de Jong, MA; Doornaert, P; Terhaard, CHJ; Steenbakkers, RJHM; Hamming-Vrieze, O; van de Kamer, JB; Verbakel, WFAR; Keskin-Cambay, F; Reitsma, JB; van der Schaaf, A; Boersma, LJ; Schuit, E, National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer, International Journal of Particle Therapy, 2021, https://doi.org/10.14338/IJPT-20-00089.1

Collado-Lara, G; Heymans, SV; Godart, J; D’Agostino, E; D’hooge, J; Van Den Abeele, K; Vos, HJ; de Jong, N, Effect Of A Radiotherapeutic Megavoltage Beam On Ultrasound Contrast Agents, Ultrasound In Medicine And Biology, 2021, https://doi.org/10.1016/j.ultrasmedbio.2021.02.021

Eekers, DBP; Di Perri, D; Roelofs, E; Postma, A; Dijkstra, J; Ajithkumar, T; Alapetite, C; Blomstrand, M; Burnet, NG; Calugaru, V; Compter, I; Coremans, IEM; Harrabi, S; Iannalfi, A; Klaver, YLB; Lambrecht, M; Romero, AM; Paulsen, F; Timmermann, B; Vitek, P; van der Weide, HL; Whitfield, GA; Nyström, PW; Zindler, J; de Ruysscher, D; Langendijk, J; Weber, DC; Troost, EGC, Update of the EPTN atlas for CT- and MR-based contouring in Neuro-Oncology, Radiotherapy and Oncology, 2021, https://doi.org/10.1016/j.radonc.2021.05.013.

Carlino, A; Palmans, H; Gouldstone, C; Trnkova, P; Noerrevang, O; Vestergaard, A; Freixas, GV; Bosmans, G; Lorentini, S; Schwarz, M; Koska, B; Wulff, J; Vatnitsky, S; Stock, M, Results of an independent dosimetry audit for scanned proton beam therapy facilities, Zeitschrift fur Medizinische Physik, 2021, https://doi.org/10.1016/j.zemedi.2021.01.003

Kouwenberg, J; Penninkhof, J; Habraken, S; Zindler, J; Hoogeman, M; Heijmen, B, Model based patient pre-selection for intensity-modulated proton therapy (IMPT) using automated treatment planning and machine learning, Radiotherapy and Oncology, 2021, https://doi.org/10.1016/j.radonc.2021.02.034.

Berger, T; Godart, J; Jagt, T; Vittrup, AS; Fokdal, LU; Lindegaard, JC; Jensen, NBK; Zolnay, A; Reijtenbagh, D; Trnkova, P; Tanderup, K; Hoogeman, M, Dosimetric Impact of Intrafraction Motion in Online-Adaptive Intensity Modulated Proton Therapy for Cervical Cancer, International Journal of Radiation Oncology Biology Physics, 2021, https://doi.org/10.1016/j.ijrobp.2020.11.037.

’t Ven, LI; Roelofs, E; Mesías, MC; Compter, I; Klaver, YLB; Smeenk, RJ; Janssens, GO; Kaanders, JHAM; Fajardo, RD; Oldenburger, F; de Ruysscher, D; Troost, EGC; Eekers, DBP, The ROCOCO performance scoring system translates dosimetric differences into clinically relevant endpoints: Comparing IMPT to VMAT in an example pilocytic astrocytoma dataset, Clinical and Translational Radiation Oncology, 2021, https://doi.org/10.1016/j.ctro.2021.02.006.

Jaspers, JPM; Romero, AM; Wiggenraad, R; Compter, I; Eekers, DBP; Nout, RA; van den Bent, MPattern of failure in IDH mutated, low grade glioma after radiotherapy – Implications for margin reduction, Radiotherapy and Oncology, 2021, https://doi.org/10.1016/j.radonc.2020.11.019.

den Boer, E; Wulff, J; Mäder, U; Engwall, E; Bäumer, C; Perko, Z; Timmermann, B, Technical Note: Investigating interplay effects in pencil beam scanning proton therapy with a 4D XCAT phantom within the RayStation treatment planning system, Medical Physics, 2021, https://doi.org/10.1002/mp.14709.

Niyoteka, S; Berger, T; Fokdal, LU; Petersen, JBB; Zolnay, A; Hoogeman, M; Tanderup, K; Nystrom, HU, Impact of interfractional target motion in locally advanced cervical cancer patients treated with spot scanning proton therapy using an internal target volume strategy, Physics & Imaging In Radiation Oncology, 2021, https://doi.org/10.1016/j.phro.2021.01.010.

Fleury, E; Trnková, P; Erdal, E; Hassan, M; Stoel, B; Jaarma-Coes, M; Luyten, G; Herault, J; Webb, A; Beenakker, JW; Pignol, JP; Hoogeman, M, Three-dimensional MRI-based treatment planning approach for non-invasive ocular proton therapy, Medical Physics, 2021, https://doi.org/10.1002/mp.14665

Klaassen, L; Petoukhova, AL; Habraken, SJM; Jacobs, J; Sattler, MGA; Verhoeven, K; Klaver, YLB, Effect of breathing motion on robustness of proton therapy plans for left-sided breast cancer patients with indication for locoregional irradiation, Acta Oncologica, 2021, https://doi.org/10.1080/0284186X.2020.1825800

van der Weide, HL; Kramer, MCA; Scandurra, D; Eekers, DBP; Klaver, YLB; Wiggenraad, RGJ; Romero, AM; Coremans, IEM; Boersma, L; van Vulpen, M; Langendijk, JA, Proton therapy for selected low grade glioma patients in the Netherlands, Radiotherapy and Oncology, 2021, https://doi.org/10.1016/j.radonc.2020.11.004

Missiaggia, M; Cartechini, G; Scifoni, E; Rovituso, M; Tommasino, F; Verroi, E; Durante, M; La Tessa, C, Microdosimetric measurements as a tool to assess potential in-field and out-of-field toxicity regions in proton therapy, Physics In Medicine and Biology, 2020, https://doi.org/10.1088/1361-6560/ab9e56.

Civinini, C; Scaringella, M; Brianzi, M; Intravaia, M; Randazzo, N; Sipala, V; Rovituso, M; Tommasino, F; Schwarz, M; Bruzzi, M, Relative stopping power measurements and prosthesis artifacts reduction in proton CT, Physics in Medicine and Biology, 2020, https://doi.org/10.1088/1361-6560/abb0c8.

Palmans, H; Medin, J; Trnková, P; Vatnitsky, S, Gradient corrections for reference dosimetry using Farmer-type ionization chambers in single-layer scanned proton fields, Medical Physics, 2020, https://doi.org/10.1002/mp.14554.

Jaarsma-Coes, MG; Marinkovic, M; Astreinidou, E; Schuurmans, MS; Peters, FP; Luyten, GPM; Rasch, CRN; Beenakker, JWM, Measuring eye deformation between planning and proton beam therapy position using magnetic resonance imaging, Physics & Imaging In Radiation Oncology, 2020, https://doi.org/10.1016/j.phro.2020.09.010.

Jagt, TZ; Breedveld, S; van Haveren, R; Heijmen, BM; Hoogeman, MS, Online-adaptive versus robust IMPT for prostate cancer: How much can we gain?, Radiotherapy And Oncology, 2020, https://doi.org/10.1016/j.radonc.2020.07.054.

van der Bijl, E; Wang, YB; Janssen, T; Petit, S, Predicting patient specific Pareto fronts from patient anatomy only, Radiotherapy and Oncology, 2020, https://doi.org/10.1016/j.radonc.2020.05.050.

Lens, E; Tolboom, E; Schaart, DR, An Approach for Optimizing Prompt Gamma Photon-Based Range Estimation in Proton Therapy Using Cramer-Rao Theory, IEEE Transactions On Radiation And Plasma Medical Sciences, 2020, https://doi.org/10.1109/TRPMS.2019.2921634.

Florijn, MA; Sharfo, AWM; Wiggenraad, RGJ; van Santvoort, JPC; Petoukhova, AL; Hoogeman, MS; Mast, ME; Dirkx, MLP, Lower doses to hippocampi and other brain structures for skull-base meningiomas with intensity modulated proton therapy compared to photon therapy, Radiotherapy And Oncology, 2020, https://doi.org/10.1016/j.radonc.2019.08.019.

Fonk, LG; Ferreira, TA; Webb, AG; Luyten, GPM; Beenakker, JWM, The Economic Value of MR-Imaging for Uveal Melanoma, Clinical Ophthalmology, 2020, https://doi.org/10.2147/OPTH.S238405.

Troost, EGC; Wink, KCJ; Roelofs, E; Simone, CB; Makocki, S; Löck, S; van Kollenburg, P; Dechambre, D; Minken, AWH; van der Stoep, J; Avery, S; Jansen, N; Solberg, T; Bussink, J; de Ruysscher, D, Photons or protons for reirradiation in (non-)small cell lung cancer: Results of the multicentric ROCOCO in-silico study, British Journal of Radiology, 2020, https://doi.org/10.1259/bjr.20190879.

Chuong, M; Kaiser, A; Molitoris, J; Romero, AM; Apisarnthanarax, S, Proton beam therapy for liver cancers, Journal of Gastrointestinal Oncology, 2020, https://doi.org/10.21037/jgo.2019.04.02.

Jaarsma-Coes, MG; Ferreira, TAG; van Haren, GR; Marinkovic, M; Beenakker, JWM, MRI enables accurate diagnosis and follow-up in uveal melanoma patients after vitrectomy, Melanoma Research, 2019, https://doi.org/10.1097/CMR.0000000000000568.

Korevaar, EW; Habraken, SJM; Scandurra, D; Kierkels, RGJ; Unipan, M; Eenink, MGC; Steenbakkers, RJHM; Peeters, SG; Zindler, JD; Hoogeman, M; Langendijk, JA, Practical robustness evaluation in radiotherapy – A photon and proton-proof alternative to PTV-based plan evaluation, Radiotherapy And Oncology, 2019, https://doi.org/10.1016/j.radonc.2019.08.005.

Qiao, YC; Jagt, T; Hoogeman, M; Lelieveldt, BPF; Staring, M, Evaluation of an Open Source Registration Package for Automatic Contour Propagation in Online Adaptive Intensity-Modulated Proton Therapy of Prostate Cancer, Frontiers In Oncology, 2019, https://doi.org/10.3389/fonc.2019.01297.

van Dongen, KWA; de Blécourt, J; Lens, E; Schaart, DR; Vos, FM, Reconstructing 3D proton dose distribution using ionoacoustics, Physics In Medicine and Biology, 2019, https://doi.org/10.1088/1361-6560/ab4cd5.

Horst, F; Adi, W; Aricò, G; Brinkmann, KT; Durante, M; Reidel, CA; Rovituso, M; Weber, U; Zaunick, HG; Zink, K; Schuy, C, Measurement of PET isotope production cross sections for protons and carbon ions on carbon and oxygen targets for applications in particle therapy range verification, Physics In Medicine and Biology, 2019, https://doi.org/10.1088/1361-6560/ab4511.

Gutierrez, A; Rompokos, V; Li, K; Gillies, C; D’Souza, D; Solda, F; Fersht, N; Chang, YC; Royle, G; Amos, RA; Underwood, T, The impact of proton LET/RBE modeling and robustness analysis on base-of-skull and pediatric craniopharyngioma proton plans relative to VMAT, Acta Oncologica, 2019, https://doi.org/10.1080/0284186X.2019.1653496.

Elmahdy, MS; Jagt, T; Zinkstok, RT; Qiao, YC; Shahzad, R; Sokooti, H; Yousefi, S; Incrocci, L; Marijnen, CAM; Hoogeman, M; Staring, M, Robust contour propagation using deep learning and image registration for online adaptive proton therapy of prostate cancer, Medical Physics, 2019, https://doi.org/10.1002/mp.13620.

Jagt, TZ; Breedveld, S; van Haveren, R; Nout, RA; Astreinidou, E; Heijmen, BM; Hoogeman, MS, Plan-library supported automated replanning for online-adaptive intensity-modulated proton therapy of cervical cancer, Acta Oncologica, 2019, https://doi.org/10.1080/0284186X.2019.1627414.

Chuong, MD; Kaiser, A; Khan, F; Parikh, P; Ben-Josef, E; Crane, C; Brunner, T; Okumura, T; Schreuder, N; Bentzen, SM; Gutierrez, A; Romero, AM; Yoon, SM; Sharma, N; Kim, TH; Kishi, K; Moeslein, F; Hoffe, S; Schefter, T; Hanish, S; Scorsetti, M; Apisarnthanarax, S, Consensus Report From the Miami Liver Proton Therapy Conference, Frontiers In Oncology, 2019, https://doi.org/10.3389/fonc.2019.00457.

Lens, E; Jagt, TZ; Hoogeman, MS; Schaart, DR, Correlations between the shifts in prompt gamma emission profiles and the changes in daily target coverage during simulated pencil beam scanning proton therapy, Physics In Medicine and Biology, 2019, https://doi.org/10.1088/1361-6560/ab145e.

Qiao, YC; Lelieveldt, BPF; Staring, M, An Efficient Preconditioner for Stochastic Gradient Descent Optimization of Image Registration, IEEE Transactions On Medical Imaging, 2019, https://doi.org/10.1109/TMI.2019.2897943.

Elmahdy, MS; Wolterink, JM; Sokooti, H; Išgum, I; Staring, M, Adversarial Optimization for Joint Registration and Segmentation in Prostate CT Radiotherapy, MICCAI, 2019

Lopes, PC; Crespo, P; Simoes, H; Marques, RF; Parodi, K; Schaart, DR, Simulation of proton range monitoring in an anthropomorphic phantom using multi-slat collimators and time-of-flight detection of prompt-gamma quanta, Physica Medica – European Journal of Medical Physics, 2018, https://doi.org/10.1016/j.ejmp.2018.09.001.

Trnková, P; Knäusl, B; Actis, O; Bert, C; Biegun, AK; Boehlen, TT; Furtado, H; McClelland, J; Mori, S; Rinaldi, I; Rucinski, A; Knopf, AC, Clinical implementations of 4D pencil beam scanned particle therapy: Report on the 4D treatment planning workshop 2016 and 2017, Physica Medica – European Journal of Medical Physics, 2018, https://doi.org/10.1016/j.ejmp.2018.10.002.

Lopes, PC; Crespo, P; Huizenga, J; Schaart, DR, Optimization of the Signal-to-Background Ratio in Prompt Gamma Imaging Using Energy and Shifting Time-of-Flight Discrimination: Experiments With a Scanning Parallel-Slit Collimator, IEEE Transactions on Radiation And Plasma Medical Sciences, 2018, https://doi.org/10.1109/TRPMS.2018.2846612.

Eekers, DBP; in ’t Ven, L; Roelofs, E; Postma, A; Alapetite, C; Burnet, NG; Calugaru, V; Compter, I; Coremans, IEM; Hoyer, M; Lambrecht, M; Nyström, PW; Romero, AM; Paulsen, F; Perpar, A; de Ruysscher, D; Renard, L; Timmermann, B; Vitek, P; Weber, DC; van der Weide, HL; Whitfield, GA; Wiggenraad, R; Troost, EGC, The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology, Radiotherapy and Oncology, 2018, https://doi.org/10.1016/j.radonc.2017.12.013.

Jagt, T; Breedveld, S; van Haveren, R; Heijmen, B; Hoogeman, M, An automated planning strategy for near real-time adaptive proton therapy in prostate cancer, Physics in Medicine and Biology, 2018, https://doi.org/10.1088/1361-6560/aacaa7.

Petr, J; Platzek, I; Hofheinz, F; Mutsaerts, HJMM; Asllani, I; van Osch, MJP; Seidlitz, A; Krukowski, P; Gommlich, A; Beuthien-Baumann, B; Jentsch, C; Maus, J; Troost, EGC; Baumann, M; Krause, M; van den Hoff, J, Photon vs. proton radiochemotherapy: Effects on brain tissue volume and perfusion, Radiotherapy and Oncology, 2018, https://doi.org/10.1016/j.radonc.2017.11.033.

Langendijk, JA; Boersma, LJ; Rasch, CRN; van Vulpen, M; Reitsma, JB; van der Schaaf, A; Schuit, E, Clinical Trial Strategies to Compare Protons With Photons, Seminars In Radiation Oncology, 2018, https://doi.org/10.1016/j.semradonc.2017.11.008.

Perkó, Z; Bortfeld, T; Hong, T; Wolfgang, J; Unkelbach, J, Derivation of mean dose tolerances for new fractionation schemes and treatment modalities, Physics In Medicine And Biology, 2018, https://doi.org/10.1088/1361-6560/aa9836.

van de Water, S; Albertini, F; Weber, DC; Heijmen, BM; Hoogeman, MS; Lomax, AJ, Anatomical robust optimization to account for nasal cavity filling variation during intensity-modulated proton therapy: a comparison with conventional and adaptive planning strategies, Physics In Medicine And Biology, 2018, https://doi.org/10.1088/1361-6560/aa9c1c.

Lambrecht, M; Eekers, DBP; Alapetite, C; Burnet, NG; Calugaru, V; Coremans, IEM; Fossati, P; Hoyer, M; Langendijk, JA; Romero, AM; Paulsen, F; Perpar, A; Renard, L; de Ruysscher, D; Timmermann, B; Vitek, P; Weber, DC; van der Weide, HL; Whitfield, GA; Wiggenraad, R; Roelofs, E; Nyström, PW; Troost, EGC, Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus, Radiotherapy and Oncology, 2018, https://doi.org/10.1016/j.radonc.2018.05.00.

Boersma LJ, van Vulpen M, Rasch CRN, Langendijk JLA, Proton therapy centres opened; what next?, Ned Tijdschr Geneeskd, 2018.

Elmahdy, MS; Jagt, T; Yousefi, S; Sokooti, H; Zinkstok, R; Hoogeman, M; Staring, M, Evaluation of Multi-metric Registration for Online Adaptive Proton Therapy of Prostate Cancer, Biomedical Image Registration. WBIR, 2018. Lecture Notes in Computer Science, vol 10883, 2018