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Research

How HollandPTC works to enhance the benefits of proton therapy

 

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HollandPTC

HollandPTC

Voor de beste protonentherapie van nu en later

Over HollandPTC
Onze visie: Samen beter, beter samen Ons team HollandPTC software
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SAMEN BETER, BETER SAMEN

Patiënten

Patientenzorg

Gezond weefsel beter sparen Dat is het voordeel van protonentherapie.

Bekijk
Over de behandeling Waarom protonentherapie Algemene informatie Soorten kanker Ervaringen van patiënten Tips en adviezen Second opinion Jongvolwassen en kanker Lopende studies
Uw bezoek aan HollandPTC Locatie en contactgegevens Wat neemt u mee Vervoer en overnachten Compliment of klacht
Praktische informatie Vergoeding van uw behandeling Uw dossier Patiëntenervaringen
Research

Research

How HollandPTC works to enhance the benefits of proton therapy

 

View
Research at HollandPTC Research projects Organisations & collaborations Our researchers Publication list
Facilities Pre-clinical and clinical facilities Our research database: how to request data Doing proton research or use our facilities
Practical information Practical information on Varian projects R&D communication box
HollandPTC

HollandPTC

Voor de beste protonentherapie van nu en later

Over HollandPTC
Over HollandPTC Onze visie: Samen beter, beter samen Ons team HollandPTC software
Cliëntenraad HollandPTC foundation Diversiteit en gelijkheid Contact

Influence of intrinsic biological variability on the outcomes of proton radiotherapy in head and neck cancer

 

Principal Investigators: dr. Dik van Gent (Erasmus MC), dr. ir. Danny Lathouwers (TU Delft), dr. Jeremy Brown (TU Delft), dr. Danny Lathouwers (TU Delft)

PhD students: Katrin Pachler (Erasmus MC), Celebrity Groenendijk (TU Delft), Mieke Bavelaar (Erasmus MC)

Funding: HollandPTC – Varian 2019

Description

The main aim of this project is to identify biological factors that influence the outcomes of proton radiotherapy in head and neck squamous cell carcinoma (HNSCC) and use them to develop a predictive framework to estimate cellular/tissue response as a function of linear energy transfer (LET) and dose (rate).

We will achieve this by addressing the following questions:

  • What types of DNA damage occur after proton irradiation of different LET and/or position relative to Bragg peak and which pathways are involved in their repair?
  • How pronounced is the inter-patient heterogeneity in tumor response to proton irradiation and can it be correlated with specific molecular traits?
  • Can we predict the relative sensitivity of individual tumors to proton versus photon therapy?